I'm running the 5.29's, 4:1 and an auto tranny. It works great with the V-6 and 37's.... I almost went with a lower gear (5.71) but the auto make up for it. (and I've heard rumors they are a weak design)
I would not use the 4.10's... The lower RPM wont necessarily save you gas. If you are under geared like the 4.10's will be, you will just be running in 4th instead of 5th on the interstate (and have REAL weak acceleration).
I ran stock gearing (5.13's) on my Kick with 33's and it was weak... very weak on road and soft off road too. That would be very comparable to the difference in your stock gears and dropping to 4.10's (about 20%) if you stayed with the same tires.
Are you auto or manual? What tires are you planning on running?
HTH,
Zig