to paraphrase Yankee tim:
NO!
You would be trading almost no gain in reducing drivetrain wear for extreme wear caused by exposing your outer wheel bearings to the elements!
Even if you pulled your CV shafts instead, you would be exposing your inboard wheel bearings to the same fate if you did not install a block-off cap as found on a 2wd hub. Unfortunately, if you DO pull the CV shafts AND install the caps, you will be exposing the inside of the front differential directly to the elements through the CV shaft opening on the passenger side!
Seriously, if you want better mileage, keep your engine tuned up, change your oil and lubricants at the proper scheduled intervals and keep your tires properly inflated.