How many miles are on your beast? WHEN do you feel/hear the vibration come on? On acceleration? When decellerating? All the time when you're truck is moving? When cruising down the highway... with the stereo off? Do you feel it in your seat? In the shifter? Is it worse in the back seat area?
The reason i ask these dumb questions is simply when and where you feel/hear the vibration is important too. Could simply be one of your tires threw a tire weight. You won't necessarly feel it at low speeds, but as you accellerate, it will become more pronounced.
Unless you have a lot of miles on your truck, or pull a lot of hole shots with it, or tow alot with it, or do alot of wheeling through deep water, your u-joints should still be hanging strong through 125K miles.
Have you inspected the u-joint visually and tried to shake the coupling? Check out some other areas too before you decide it's one of the u-joints.